circRNA basic information
circBase ID: -
Name: hsa_circ_ATRNL1
Synonym: circ100686
Host Gene: ATRNL1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004992
MONDO name: cancer
Disease details: human cancer
Disease DO ID:
 0050686, 0050687, 162
Disease MeSH ID:
 -
Disease NCIt ID:
 C9305
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal colon mucosa
Cell lines:

HCT-116; DKO
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-378a-3p
Biological function: acts as miRNA decoy
Molecular mechanism: Promoter CpG island hypermethylation of ATRNL1 is linked to downregulation of ATRNL1 circ100686; circRNA reactivation is associated with reduced complementary miRNA (hsa-miR-378a-3p)
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Bioinformatics Analysis
Clinical significance:

-
Description:

ATRNL1 circ100686 is downregulated in methylated HCT-116 cancer cells and reactivated in DNMT-deficient DKO cells. Its silencing/reactivation correlates inversely with its complementary miRNA hsa-miR-378a-3p, supporting a miRNA-decoy role.
Confidence score:

0.5193
Other information
Title:

Circular RNA CpG island hypermethylation-associated silencing in human cancer.

Journal: Oncotarget
Published: 2018
PubMed ID: 30018746
Study type:

combined biological and clinical study
Data availability: GSE109676
Code availability: -