circRNA basic information
circBase ID: hsa_circ_0000419
Name: hsa_circ_RAB3IP
Synonym: -
Host Gene: RAB3IP
Genomic location(hg19): chr12:70193988-70195501:+
Genomic location(hg38): chr12:69800208-69801721:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006337
MONDO name: ovarian endometriosis
Disease details: ovarian endometriosis
Disease DO ID:
 11432
Disease MeSH ID:
 -
Disease NCIt ID:
 C27628
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ectopic endometrium tissues; eutopic endometrium tissues; normal endometrium
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: mRNAs
Associated microRNA: miR-141-5p
Biological function: may regulated epithelial-mesenchymal transition in endometriosis; might contribute to the pathogenesis of endometriosis by inducing autophagy
Molecular mechanism: circRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network via miR-141-5p
Biological pathway or process:

EMT (other); autophagy (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circ_101102 (derived from RAB3IP) is down-regulated in endometriosis and its differential expression was validated by qRT-PCR. The study proposes it may regulate epithelial-mesenchymal transition via miR-141-5p in a ceRNA network, and discusses a possible link to autophagy in endometriosis.
Confidence score:

0.4032
Other information
Title:

Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics.

Journal: Medical science monitor : international medical journal of experimental and clinical research
Published: 2018
PubMed ID: 30566420
Study type:

combined biological and clinical study
Data availability: -
Code availability: -