| Expression pattern: |
UP |
| Associated gene: |
MAP3K3, Ago2 |
| Associated microRNA: |
miR-129-3p |
| Biological function: |
promotes proliferation, invasion and migration; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circSETDB1 acts as a sponge for miR-129-3p to upregulate MAP3K3 (ceRNA-like regulation). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circSETDB1 is up-regulated in serous ovarian cancer and functions as an oncogenic circRNA. It sponges miR-129-3p to increase MAP3K3 expression, thereby promoting proliferation, migration and invasion and inhibiting apoptosis; circSETDB1 knockdown suppresses tumor growth in vivo. |
| Confidence score: |
0.8006 |