circRNA basic information
circBase ID: hsa_circ_0002017
Name: hsa_circ_CRIM1
Synonym: hsa_circRNA_102677
Host Gene: CRIM1
Genomic location(hg19): chr2:36623756-36623930:+
Genomic location(hg38): chr2:36396613-36396787:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent-normal tissues
Cell lines:

A549; SK-MES-1; HFL1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ARRB1, FNBP1, FZD4, HERC1
Associated microRNA: hsa-miR-767-3p, hsa-miR-767-5p
Biological function: not specified
Molecular mechanism: Construction of a circRNA-miRNA-mRNA ceRNA network involving down-regulated circRNAs and up-regulated miRNAs in NSCLC.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0002017 is a down-regulated circRNA in NSCLC identified from GEO datasets and validated by qRT-PCR in NSCLC cell lines. It was included in the constructed circRNA-miRNA-mRNA ceRNA subnetwork with key up-regulated miRNAs (hsa-miR-767-3p/5p) and prognostic mRNAs.
Confidence score:

0.4032
Other information
Title:

Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.

Journal: Cancer cell international
Published: 2021
PubMed ID: 34801043
Study type:

combined biological and bioinformatics study
Data availability: GSE101684; GSE112214
Code availability: -