| Expression pattern: |
DN |
| Associated gene: |
KLF4 |
| Associated microRNA: |
miR-29a |
| Biological function: |
inhibits cell proliferation and migration; promotes contractile phenotype markers and inhibits synthetic phenotype markers; suppresses aortic dissection progression |
| Molecular mechanism: |
ceRNA mechanism: circ_TGFBR2 sponges miR-29a to regulate KLF4 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_TGFBR2 is down-regulated in aortic dissection tissues and AD-VSMCs. It suppresses VSMC proliferation/migration and phenotypic switching by acting as a ceRNA that sponges miR-29a to regulate KLF4, and its overexpression inhibits AD progression in a BAPN-induced rat model. |
| Confidence score: |
0.8465 |