circRNA basic information
circBase ID: hsa_circ_0007422
Name: hsa_circ_SATB2
Synonym: circSATB2
Host Gene: SATB2
Genomic location(hg19): chr2:200173482-200298237:-
Genomic location(hg38): chr2:199308759-199433514:-
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100459
MONDO name: azoospermia
Disease details: non-obstructive azoospermia
Disease DO ID:
 14227
Disease MeSH ID:
 D053713
Disease NCIt ID:
 -
Disease ICD11 ID:
 532688254
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Serum hsa_circ_0007422 is lowly expressed in the failed sperm retrieval group; its over-expression in serum was reported as beneficial for successful sperm retrieval and it showed significant predictive value for SRR.
Molecular mechanism: Predicted ceRNA mechanism; bioinformatics analysis constructed a circRNA-microRNA-mRNA network and predicted enrichment of target genes in spermatogenesis-related pathways.
Biological pathway or process:

ceRNA regulation (other); Wnt/beta-catenin (other); Hippo/YAP (other); apoptosis (other); p53 signaling (other); MAPK (other); PI3K/AKT/mTOR (other); proliferation (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Serum hsa_circ_0007422 showed significant potential to predict sperm retrieval rate in NOA patients; AUC 0.831 as a single-circRNA panel.
Description:

hsa_circ_0007422 was significantly lower in serum from NOA patients with failed sperm retrieval. Higher serum expression was associated with successful sperm retrieval and it showed diagnostic/predictive utility both alone and within the six-circRNA panel.
Confidence score:

0.459
Other information
Title:

A detection model of testis-derived circular RNAs in serum for predicting testicular sperm retrieval rate in non-obstructive azoospermia patients.

Journal: Andrology
Published: 2024
PubMed ID: 38421140
Study type:

combined clinical and bioinformatics study
Data availability: available from the corresponding author upon reasonable request
Code availability: -