| Expression pattern: |
UP |
| Associated gene: |
Wnt5A |
| Associated microRNA: |
hsa-miR-136-5p |
| Biological function: |
Inhibits normal hair follicle growth; mediates hair loss in AGA (proposed) via sponging miR-136-5p and upregulating Wnt5A. |
| Molecular mechanism: |
Potential ceRNA (sponging) mechanism: hsa_circ_0001079 binds (sponges) hsa-miR-136-5p, relieving inhibition of Wnt5A. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); DNA replication (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay |
| Clinical significance: |
ROC analysis indicated that hsa_circ_0001079 was of great value in the diagnosis of AGA, suggesting that hsa_circ_0001079 is a potential clinical diagnostic marker of alopecia. |
| Description: |
hsa_circ_0001079 is significantly up-regulated in hair follicles from androgenetic alopecia patients and shows diagnostic potential by ROC analysis. Mechanistically, it is predicted to sponge hsa-miR-136-5p, thereby relieving miRNA repression of Wnt5A and potentially inhibiting hair follicle growth. |
| Confidence score: |
0.6709 |