| Expression pattern: |
UP |
| Associated gene: |
ABL2, Ago2 |
| Associated microRNA: |
miR-107 |
| Biological function: |
promotes WT cell viability/proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circSLC7A6 acts as a ceRNA to sponge miR-107, thereby upregulating ABL2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
potential therapeutic target for WT |
| Description: |
circSLC7A6 is up-regulated in Wilms’ tumor tissues and cell lines and promotes malignant phenotypes (proliferation/viability, migration, invasion) while suppressing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-107 to upregulate ABL2, and its knockdown inhibits xenograft tumor growth. |
| Confidence score: |
0.7365 |