| Expression pattern: |
UP |
| Associated gene: |
ANXA11, Ago2, CD8 + T cell, PD-1, MMP2, MMP9 |
| Associated microRNA: |
miR-497-5p |
| Biological function: |
CircSOD2 promotes HCC cell proliferation, colony formation, cell cycle progression, migration, invasion, metastasis, tumor growth, immune evasion and anti-PD-1 resistance, and inhibits apoptosis and CD8 + T cell viability. |
| Molecular mechanism: |
CircSOD2 acts as a miR-497-5p sponge to upregulate ANXA11 expression, thereby promoting HCC progression, immune evasion and anti-PD-1 resistance. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes); immune regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; circRNA-seq; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
CircSOD2 may be a biomarker for immune evasion and anti-PD-1 resistance and may contribute to HCC diagnosis and immunotherapeutic effect. |
| Description: |
CircSOD2 is upregulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC growth, metastasis, immune evasion and anti-PD-1 resistance by sponging miR-497-5p and increasing ANXA11 expression. Its high expression is associated with reduced CD8 + T cell frequency and potential immunotherapeutic resistance. |
| Confidence score: |
0.8572 |