| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miRNA-142 |
| Biological function: |
Associated with higher disease risk, greater disease severity, increased inflammation, and higher recurrence risk in acute ischemic stroke. |
| Molecular mechanism: |
Not experimentally explored in this study; discussion suggests a potential miRNA sponge role (e.g., miRNA-142) and involvement in inflammation/immune responses. |
| Biological pathway or process: |
inflammation (promotes); immune regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; ELISA |
| Clinical significance: |
circRNA HECTD1 expression differentiates AIS patients from controls (AUC 0.814) and predicts higher risk of AIS recurrence (AUC 0.694); high expression is associated with shorter recurrence-free survival. |
| Description: |
In PBMCs from acute ischemic stroke patients, circRNA HECTD1 is up-regulated versus controls and correlates with NIHSS score and pro-inflammatory markers. Higher circRNA HECTD1 is associated with increased recurrence risk and shorter recurrence-free survival, supporting its potential as a clinical biomarker in AIS. |
| Confidence score: |
0.5802 |