| Expression pattern: |
UP |
| Associated gene: |
FAM98A |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
promotes proliferation, migration, invasion and angiogenesis and inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circ-IFT80 sequesters miR-545-3p to upregulate FAM98A |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ-IFT80 expression was closely correlated with the TNM stage, histological grade, myometrial invasion, and lymphatic metastasis of the tumors |
| Description: |
circ-IFT80 is up-regulated in endometrial cancer and promotes malignant phenotypes (proliferation, migration, invasion, angiogenesis) while inhibiting apoptosis. Mechanistically, it acts as a cytoplasmic miRNA sponge for miR-545-3p, relieving repression of FAM98A and thereby enhancing tumor progression, including xenograft growth. |
| Confidence score: |
0.8175 |