| Expression pattern: |
UP |
| Associated gene: |
TGF-beta1 |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
Promotes invasion, migration and EMT; promotes cisplatin resistance (reduces apoptosis and increases viability) in OSCC cells. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-515-5p, thereby regulating TGF-beta1 expression and related EMT/metastatic potential and cisplatin resistance. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; CCK8; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; ELISA |
| Clinical significance: |
circANKS1B may be a promising target for therapy and overcoming chemoresistance in OSCC. |
| Description: |
circANKS1B is up-regulated in OSCC tissues/cells and promotes metastatic phenotypes (invasion, migration, EMT). It increases cisplatin resistance by supporting viability and suppressing apoptosis, acting as a ceRNA that sponges miR-515-5p to relieve repression of TGF-beta1. |
| Confidence score: |
0.705 |