| Expression pattern: |
DN |
| Associated gene: |
CTCF, c-Myc |
| Associated microRNA: |
miR-3942, miR-3942-5p |
| Biological function: |
Inhibits ccRCC tumor growth, proliferation, migration, invasion, EMT, and metastasis. |
| Molecular mechanism: |
circESRP1 acts as a ceRNA sponge for miR-3942/miR-3942-5p to upregulate CTCF; CTCF binds ESRP1 promoter to promote circESRP1 transcription forming a positive feedback loop; axis regulates c-Myc-mediated EMT. |
| Biological pathway or process: |
EMT (inhibits); metastasis (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; ChIP / ChIP-seq; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study |
| Clinical significance: |
Lower circESRP1 expression is associated with advanced tumor size, TNM stage, distant metastasis, and poor prognosis; high circESRP1 expression is associated with favorable clinical outcomes. |
| Description: |
circESRP1 is down-regulated in ccRCC and functions as a tumor suppressor. It sponges miR-3942/miR-3942-5p to relieve repression of CTCF, while CTCF transcriptionally promotes circESRP1 to form a positive feedback loop that inhibits c-Myc-mediated EMT and ccRCC progression. |
| Confidence score: |
0.8972 |