circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: circUBAP2
Host Gene: UBAP2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

U251; MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Downregulation of an oncogenic circRNA in U251 and MCF-7 cells after nitrogenous heterocyclic compound treatment (drug-associated suppression).
Molecular mechanism: Not specified; circUBAP2 is described as an oncogene and linked to MAPK/ERK in a pathway table, but no direct mechanistic assays were reported.
Biological pathway or process:

MAPK/ERK (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

In U251 glioma and MCF-7 breast cancer cells, the nitrogenous heterocyclic compound downregulated circUBAP2, which the authors describe as an oncogenic circRNA and associate with MAPK/ERK signaling in their pathway table.
Confidence score:

0.4635
Other information
Title:

Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.

Journal: Drug design, development and therapy
Published: 2018
PubMed ID: 29983547
Study type:

biological research
Data availability: -
Code availability: -