| Expression pattern: |
UP |
| Associated gene: |
ERBB4, PI3K, AKT, IGF2BP2 |
| Associated microRNA: |
miR-3187-3p |
| Biological function: |
promotes proliferation, migration, invasion, EMT, aggressiveness, stemness and tumorigenesis of ovarian cancer cells |
| Molecular mechanism: |
circ_0000745 acts as a ceRNA to sponge miR-3187-3p, derepressing ERBB4 and activating PI3K/AKT signaling; IGF2BP2 binds circ_0000745 and enhances its expression/stability |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); stemness (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000745 expression was correlated with advanced FIGO stage and pathological grades |
| Description: |
circ_0000745 is upregulated in ovarian cancer tissues and cell lines and promotes malignant phenotypes including proliferation, migration/invasion, EMT, and stemness. Mechanistically, it sponges miR-3187-3p to increase ERBB4 and activate PI3K/AKT signaling, and IGF2BP2 binds circ_0000745 to enhance its abundance/stability. |
| Confidence score: |
0.8174 |