| Expression pattern: |
DS |
| Associated gene: |
AGR2, ENPP1, PPP1R9A, APOE, AQP3, CD99L2, IGFBP4 |
| Associated microRNA: |
hsa-mir-539-3p, hsa-miR-545-3p |
| Biological function: |
promotes epithelial differentiation; increases cell-to-cell adhesion; inhibits growth/proliferation; reduces random and directional motility |
| Molecular mechanism: |
Transcriptomic regulation of ~110 common genes; proposed miRNA sponging affecting AGR2/ENPP1/PPP1R9A (in silico prediction, not functionally confirmed). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA-seq; Bioinformatics Analysis; Transfection; MTT; Wound Healing Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circDOCK1-1 (hsa_circ_0020397), derived from DOCK1, is high in luminal/epithelial breast cancer cell lines but low/undetectable in triple-negative mesenchymal lines. Overexpression promotes epithelial differentiation and cell-cell adhesion while inhibiting proliferation and motility, accompanied by transcriptomic changes in a common set of genes; a miRNA-sponge ceRNA mechanism is proposed in silico (e.g., involving hsa-mir-539-3p and hsa-miR-545-3p) but not functionally confirmed. |
| Confidence score: |
0.5008 |