circRNA basic information
circBase ID: -
Name: hsa_circ_ITGA7
Synonym: circ 255-ITGA7
Host Gene: ITGA7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004981
MONDO name: atrial fibrillation
Disease details: atrial fibrillation
Disease DO ID:
 0060224
Disease MeSH ID:
 D001281
Disease NCIt ID:
 C50466
Disease ICD11 ID:
 171698302
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

left atrial appendage / LAA
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation
Clinical significance:

-
Description:

circ 255-ITGA7 is significantly down-regulated in left atrial appendage tissue from VHD patients with persistent AF compared with sinus rhythm controls. The study validates its differential expression by RT-qPCR and confirms its back-splice junction by Sanger sequencing, but does not define a specific miRNA/mRNA axis for this circRNA.
Confidence score:

0.5541
Other information
Title:

Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.

Journal: Frontiers in cardiovascular medicine
Published: 2020
PubMed ID: 33330659
Study type:

combined biological and clinical study
Data availability: PRJNA667522
Code availability: -