circRNA basic information
circBase ID: hsa_circ_0000475
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr13:37614541-37625720:-
Genomic location(hg38): chr13:37040404-37051583:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTPRB
Associated microRNA: miR-665
Biological function: Proposed to be involved in HCC tumorigenesis; its down-regulation may contribute to tumorigenesis via a miR-665-related mechanism.
Molecular mechanism: Proposed miRNA sponge interaction with miR-665, linked to miR-665 targeting of PTPRB.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Potential diagnostic biomarker for HCC in serum; ROC AUC 0.679 with sensitivity 78.3% and specificity 56%.
Description:

In serum from Egyptian HCC patients, hsa_circ_0000475 is significantly down-regulated and shows modest diagnostic performance by ROC analysis. The paper proposes that hsa_circ_0000475 may sponge miR-665, which is linked to regulation of the tumor suppressor target PTPRB, suggesting a possible role in HCC tumorigenesis.
Confidence score:

0.4187
Other information
Title:

Circular RNAs 0064286 and 0000475: Potential Diagnostic Biomarkers in Hepatocellular Carcinoma.

Journal: Asian Pacific journal of cancer prevention : APJCP
Published: 2021
PubMed ID: 34582677
Study type:

clinical study
Data availability: The clinical and demographic data of all patients are available upon request.
Code availability: -