circRNA basic information
circBase ID: -
Name: hsa_circ_PLOD2
Synonym: circRNA PLOD2
Host Gene: PLOD2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal ovarian tissue; benign tumor tissue; borderline tumor tissue; ovarian cancer tissue
Cell lines:

CAOV3; A2780; OVCAR3; HEK293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-378
Biological function: Promotes ovarian cancer cell proliferation/growth.
Molecular mechanism: Acts as a miR-378 sponge (direct binding validated by dual-luciferase), negatively regulating miR-378 levels.
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Western Blot; Clinical Sample Validation; Transfection; MTT; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-LOPD2 (circRNA derived from PLOD2) is up-regulated in ovarian cancer tissues/cells and promotes ovarian cancer cell proliferation. Mechanistically, it directly binds miR-378 as a sponge and inversely regulates miR-378 expression.
Confidence score:

0.6369
Other information
Title:

CircRNA PLOD2 enhances ovarian cancer propagation by controlling miR-378.

Journal: Saudi journal of biological sciences
Published: 2021
PubMed ID: 34759745
Study type:

combined biological and clinical study
Data availability: -
Code availability: -