| Expression pattern: |
DN |
| Associated gene: |
FGF13, KCNB1, RNF217, SARGAP2 |
| Associated microRNA: |
hsa-miR-1204, hsa-miR-450b-3p, hsa-miR-769-3p, hsa-miR-1270 |
| Biological function: |
Acts as a potential diagnostic biomarker in colorectal cancer; proposed to act as a ceRNA/miRNA sponge via a circRNA-miRNA-mRNA network. |
| Molecular mechanism: |
ceRNA (miRNA sponge) mechanism via a circRNA-miRNA-mRNA network. |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic biomarker potential in CRC with AUC 0.83; associated with tumor grade and primary tumor site. |
| Description: |
hsa_circ_001787 is significantly down-regulated in colorectal cancer tissues and shows diagnostic value (AUC ~0.83). The study proposes that it functions as a ceRNA/miRNA sponge within a circRNA-miRNA-mRNA network involving miR-1204, miR-450b-3p, miR-769-3p and miR-1270 and downstream genes including FGF13, KCNB1, RNF217 and SARGAP2. |
| Confidence score: |
0.559 |