circRNA basic information
circBase ID: hsa_circ_0020093
Name: hsa_circ_ATRNL1
Synonym: -
Host Gene: ATRNL1
Genomic location(hg19): chr10:116879948-116889297:+
Genomic location(hg38): chr10:115120184-115129535:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006337
MONDO name: ovarian endometriosis
Disease details: ovarian endometriosis
Disease DO ID:
 11432
Disease MeSH ID:
 -
Disease NCIt ID:
 C27628
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ectopic endometrium (ecEM); eutopic endometrium (euEM); cyst walls of ovarian endometriomas
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: miR-141-3p, miR-200a-3p
Biological function: might regulate EMT in endometriosis
Molecular mechanism: ceRNA (miRNA sponge) mechanism (inferred) involving miR-141-3p/miR-200a-3p and ZEB1
Biological pathway or process:

EMT (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0020093 is significantly overexpressed in ectopic endometrium in endometriosis. The study proposes, based on ceRNA network predictions, that it may influence EMT via an inferred hsa_circ_0020093/miR-141-3p/miR-200a-3p/ZEB1 regulatory axis.
Confidence score:

0.4032
Other information
Title:

Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis.

Journal: Molecular genetics & genomic medicine
Published: 2019
PubMed ID: 31144476
Study type:

combined biological and clinical study
Data availability: -
Code availability: -