circRNA basic information
circBase ID: hsa_circ_0009932
Name: hsa_circ_MIIP
Synonym: circ-MIIP
Host Gene: MIIP
Genomic location(hg19): chr1:12082889-12092106:+
Genomic location(hg38): chr1:12022832-12032049:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumor tissues; adjacent normal tissues; adjacent healthy tissues; xenograft tumor tissues
Cell lines:

NCI-H23; A549; BEAS-2B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FAM83A, Ago2
Associated microRNA: miR-766-5p
Biological function: CircMIIP promoted NSCLC cell proliferation, migration, invasion and xenograft tumor growth, and suppressed apoptosis.
Molecular mechanism: CircMIIP acts as a molecular sponge for miR-766-5p to upregulate FAM83A expression in NSCLC cells.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

CircMIIP may be a novel potential therapeutic target for NSCLC.
Description:

CircMIIP is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis, mainly by sponging miR-766-5p to increase FAM83A expression. Its knockdown suppresses malignant phenotypes in vitro and xenograft tumor growth in vivo, suggesting therapeutic potential in NSCLC.
Confidence score:

0.7554
Other information
Title:

CircMIIP Contributes to Non-Small Cell Lung Cancer Progression by Binding miR-766-5p to Upregulate FAM83A Expression.

Journal: Lung
Published: 2022
PubMed ID: 35013754
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request; https://doi.org/10.1007/s00408-021-00500-3
Code availability: -