| Expression pattern: |
UP |
| Associated gene: |
Ago2 |
| Associated microRNA: |
miR-150-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes TGF-beta-induced EMT |
| Molecular mechanism: |
acts as a miRNA sponge for miR-150-5p (ceRNA-like repression of miR-150-5p) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Clinical Sample Validation |
| Clinical significance: |
High circVANGL1 expression was associated with larger tumour thickness, advanced TNM stage and lymphatic metastasis in melanoma patients. |
| Description: |
circVANGL1 is up-regulated in melanoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) and TGF-beta-induced EMT. Mechanistically, circVANGL1 predominantly localizes to the cytoplasm and directly binds/sponges miR-150-5p; restoring miR-150-5p counteracts circVANGL1-driven effects. |
| Confidence score: |
0.7081 |