| Expression pattern: |
DN |
| Associated gene: |
HERPUD1, Ago2 |
| Associated microRNA: |
miR-370 |
| Biological function: |
promotes ER stress-induced apoptosis; suppresses proliferation; suppresses tumorigenesis |
| Molecular mechanism: |
ceRNA mechanism: circ_002117 binds (sponges) miR-370, relieving miR-370-mediated repression of HERPUD1, thereby enhancing ER stress-induced apoptosis |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); other pathway/process (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; EdU Staining; Annexin V/PI Flow Cytometry; IF (Immunofluorescence); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
Circ-002117 expression was positively correlated with overall survival rate of gastric patients. |
| Description: |
circ_002117 is down-regulated in gastric cancer tissues/cells and acts as a tumor suppressor by binding miR-370 and relieving repression of HERPUD1. Through the circ_002117/miR-370/HERPUD1 axis, it enhances ER stress-associated signaling and promotes apoptosis, thereby inhibiting gastric cancer proliferation and xenograft tumor growth. |
| Confidence score: |
0.8618 |