| Expression pattern: |
UP |
| Associated gene: |
MTDH, Ago2 |
| Associated microRNA: |
miR-3662 |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration, invasion, metastasis and EMT; inhibits apoptosis. |
| Molecular mechanism: |
circ-03955 acts as a ceRNA sponge for miR-3662, thereby indirectly upregulating MTDH and facilitating EMT. |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); Clinical Sample Validation; Microarray |
| Clinical significance: |
- |
| Description: |
circ-03955 is up-regulated in osteosarcoma tissues/cells and mainly localizes to the cytoplasm. It promotes osteosarcoma progression and EMT by sponging miR-3662 and indirectly increasing MTDH expression, thereby enhancing proliferation/migration/invasion and suppressing apoptosis. |
| Confidence score: |
0.8254 |