circRNA basic information
circBase ID: hsa_circ_0000378
Name: hsa_circ_LRP6
Synonym: circ-LRP6
Host Gene: LRP6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tissues; matched non-tumor tissues; matched normal tissues
Cell lines:

SCC-15
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: P62, LC3B, E-cadherin, vimentin, Zeb1
Associated microRNA: -
Biological function: circ-LRP6 promotes OSCC cell migration, invasion, EMT and autophagy; circ-LRP6 downregulation suppresses migration, invasion, EMT and autophagy in SCC-15 cells.
Molecular mechanism: circ-LRP6 activates autophagy, and autophagy mediates circ-LRP6-regulated EMT in OSCC cells.
Biological pathway or process:

migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); autophagy (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; IF (Immunofluorescence); Western Blot
Clinical significance:

circ-LRP6 expression was significantly correlated with clinical grade and TNM stage, and may act as a potential prognostic biomarker and therapeutic target for OSCC.
Description:

circ-LRP6 is up-regulated in OSCC tissues and its expression is associated with clinical grade and TNM stage. Functionally, circ-LRP6 promotes OSCC cell migration, invasion, EMT and autophagy, while knockdown of circ-LRP6 suppresses these malignant phenotypes. Mechanistically, autophagy participates in circ-LRP6-mediated EMT, as rapamycin partially rescues the EMT and autophagy inhibition caused by circ-LRP6 silencing.
Confidence score:

0.5414
Other information
Title:

Circ-LRP6 mediates epithelial-mesenchymal transition and autophagy in oral squamous cell carcinomas.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Published: 2021
PubMed ID: 33501755
Study type:

combined biological and clinical study
Data availability: -
Code availability: -