| Expression pattern: |
UP |
| Associated gene: |
TAGLN |
| Associated microRNA: |
miR-139-3p, miR-7-5p |
| Biological function: |
Promotes RCC cell proliferation, migration, invasion, tumor growth and metastasis. |
| Molecular mechanism: |
Acts as a ceRNA (miRNA sponge) for miR-139-3p to block miR-139-3p-mediated inhibition of TAGLN, activating PI3K/AKT signaling. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Colony Formation Assay; EdU Staining; RNA-seq; Bioinformatics Analysis; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis |
| Clinical significance: |
High ciRS-7 expression correlated with tumor size, high Fuhrman grade and poor survival. |
| Description: |
ciRS-7 (hsa_circ_0001946), derived from CDR1, is up-regulated in RCC and predominantly cytoplasmic. It promotes RCC proliferation, migration/invasion and in vivo tumor growth/metastasis by sponging miR-139-3p, relieving repression of TAGLN and activating PI3K/AKT signaling; high expression is associated with poor survival. |
| Confidence score: |
0.8711 |