| Expression pattern: |
UP |
| Associated gene: |
TRAF6 |
| Associated microRNA: |
miR-495-3p |
| Biological function: |
Aggravates LPS-induced cell injury in PDLCs: suppresses proliferation and wound healing and osteogenic differentiation; promotes apoptosis and inflammation. |
| Molecular mechanism: |
Acts as a miR-495-3p sponge to upregulate TRAF6 (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; MTT; Wound Healing Assay; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Luciferase Reporter Assay |
| Clinical significance: |
Circ_0138959 might be a probable target for treatment of periodontitis. |
| Description: |
Circ_0138959 is up-regulated in chronic periodontitis periodontal ligament tissues and in LPS-treated PDLCs, where it aggravates LPS-induced cell injury. Mechanistically, it sponges miR-495-3p to de-repress TRAF6, leading to reduced proliferation/wound healing/osteogenic differentiation and increased apoptosis and inflammation. |
| Confidence score: |
0.7412 |