circRNA basic information
circBase ID: hsa_circ_0006608
Name: hsa_circ_PFKP
Synonym: -
Host Gene: PFKP
Genomic location(hg19): chr10:3160973-3162236:+
Genomic location(hg38): chr10:3118781-3120044:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0700081
MONDO name: newborn respiratory distress syndrome
Disease details: Neonatal Acute Respiratory Distress Syndrome
Disease DO ID:
 12716
Disease MeSH ID:
 -
Disease NCIt ID:
 C27560
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Bioinformatically predicted circRNA-miRNA-mRNA network; not experimentally validated
Biological pathway or process:

inflammation (other); ceRNA regulation (other); MAPK (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential molecular marker for early diagnosis (proposed, not validated with ROC/diagnostic metrics)
Description:

hsa_circ_0006608 is down-regulated in NARDS/ARDS newborn plasma and its differential expression drift was supported by RT-qPCR in an independent set of blood samples. Predicted miRNA/mRNA interactions were generated by bioinformatics, but no direct mechanistic validation was performed for this circRNA.
Confidence score:

0.5135
Other information
Title:

Microarray and Bioinformatics Analysis of Circular RNA Differential Expression in Newborns With Acute Respiratory Distress Syndrome.

Journal: Frontiers in pediatrics
Published: 2021
PubMed ID: 34796151
Study type:

combined biological and clinical study
Data availability: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Code availability: -