| Expression pattern: |
UP |
| Associated gene: |
SLC1A5 |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
Promotes glutamine uptake and cell proliferation, inhibits apoptosis, and promotes tumor formation in breast cancer. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-149-5p to regulate SLC1A5 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); other pathway/process (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circSEPT9 expression was significantly associated with tumor size, distant metastasis, tumor-node-metastasis (TNM) stage and HER-2 status. |
| Description: |
circSEPT9 is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (glutamine uptake, proliferation, tumor growth) while inhibiting apoptosis. Mechanistically, circSEPT9 functions as a ceRNA by sponging miR-149-5p, thereby increasing SLC1A5 expression. |
| Confidence score: |
0.8006 |