circRNA basic information
circBase ID: hsa_circ_0001181
Name: hsa_circ_BACH1
Synonym: -
Host Gene: BACH1
Genomic location(hg19): chr21:30693541-30702014:+
Genomic location(hg38): chr21:29321220-29329693:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

PBMCs
Cell lines:

HepG2; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4659b-3p, hsa-miR-3614-3p, hsa-miR-4659a-3p
Biological function: May promote HCC cell proliferation; potential diagnostic biomarker; potential therapeutic target.
Molecular mechanism: Predicted as miRNA sponge within a circRNA-miRNA-mRNA network; functional effect supported by knockdown reducing HepG2 proliferation.
Biological pathway or process:

proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8
Clinical significance:

High diagnostic potential for HCC; may serve as a potential therapeutic target.
Description:

hsa_circ_0001181 is up-regulated in PBMCs from HCC patients and shows strong diagnostic performance by ROC analysis. Functionally, its knockdown in HepG2 cells suppresses proliferation, and it is incorporated into predicted ceRNA (circRNA-miRNA-mRNA) networks with specific predicted miRNA binding partners.
Confidence score:

0.6368
Other information
Title:

CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.

Journal: Experimental and therapeutic medicine
Published: 2021
PubMed ID: 34737807
Study type:

combined biological and clinical study
Data availability: PRJNA754685
Code availability: -