| Expression pattern: |
UP |
| Associated gene: |
TFAP2C, Ago2, HER2, Akt, p-Akt, ERK, p-ERK |
| Associated microRNA: |
miR-136-5p, miR-198 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth and metastasis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ-ERBB2 sponges miR-136-5p/miR-198 to relieve repression on TFAP2C, affecting HER2 and downstream Akt/ERK signaling |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); PI3K/AKT (promotes); ERK (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation |
| Clinical significance: |
circ-ERBB2 expression was interrelated to Lymph node metastasis and HER2 status in patients with HER2-positive breast cancer |
| Description: |
circ-ERBB2 (hsa_circ_0043459) is up-regulated in HER2-positive breast cancer tissues/cells and promotes proliferation, migration, invasion, and metastasis while inhibiting apoptosis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-136-5p and miR-198 to de-repress TFAP2C, increasing HER2 and activating Akt/ERK signaling; knockdown suppresses tumor growth in a BT-474 xenograft model. |
| Confidence score: |
0.7338 |