| Expression pattern: |
UP |
| Associated gene: |
CDK4, Ago2 |
| Associated microRNA: |
miR-874 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes xenograft tumor growth |
| Molecular mechanism: |
Acts as a ceRNA sponging miR-874 to upregulate CDK4 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; Flow Cytometry（Non-apoptosis/cycle） |
| Clinical significance: |
may be a promising target for HCC treatment |
| Description: |
circ_0001588 is up-regulated in HCC and functions as an oncogenic circRNA. It promotes HCC cell proliferation, migration and invasion while inhibiting apoptosis, and enhances xenograft tumor growth by sponging miR-874 to relieve repression of CDK4. |
| Confidence score: |
0.6002 |