| Expression pattern: |
DN |
| Associated gene: |
STXBP6 |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
Suppresses proliferation, migration, invasion and glycolysis; promotes apoptosis; suppresses xenograft tumor growth. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-582-3p to upregulate STXBP6. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); glycolysis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0002346 is down-regulated in NSCLC tissues/cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits proliferation, migration, invasion, and glycolysis while promoting apoptosis. Mechanistically, it sponges miR-582-3p to upregulate STXBP6 and suppresses xenograft tumor growth. |
| Confidence score: |
0.8326 |