circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: circRNA-FOXO3
Host Gene: FOXO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue samples; adjacent non-cancerous tissues
Cell lines:

A549; H1975/DDP; H1975; 16-HBE; NCI-H1650; NCI-H1299; SK-MES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: Foxo3
Associated microRNA: miR-543
Biological function: improves cisplatin (DDP) sensitivity; represses glycolysis; reduces chemoresistance
Molecular mechanism: ceRNA/sponging miR-543 to regulate Foxo3, affecting glycolysis balance and cisplatin resistance
Biological pathway or process:

glycolysis (inhibits); chemoresistance (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Microarray; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Clinical Sample Validation
Clinical significance:

-
Description:

circRNA-FOXO3 is downregulated in NSCLC tissues and in DDP-resistant cells. Its overexpression inhibits glycolysis and increases cisplatin sensitivity by sponging miR-543, thereby relieving miR-543-mediated repression of Foxo3.
Confidence score:

0.6956
Other information
Title:

Circular RNA FOXO3 accelerates glycolysis and improves cisplatin sensitivity in lung cancer cells via the miR-543/Foxo3 axis.

Journal: Oncology letters
Published: 2021
PubMed ID: 34712363
Study type:

combined biological and clinical study
Data availability: GSE182576
Code availability: -