| Expression pattern: |
UP |
| Associated gene: |
nucleophosmin 1 (NPM1) |
| Associated microRNA: |
miR-646 |
| Biological function: |
Promotes proliferation, migration, invasion and tumor growth, and inhibits apoptosis in endometrial cancer. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-646, thereby increasing NPM1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circWHSC1 is up-regulated in endometrial cancer tissues and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-646, thereby increasing the downstream target NPM1 and enhancing tumor growth in a nude mouse xenograft model. |
| Confidence score: |
0.6285 |