| Expression pattern: |
DN |
| Associated gene: |
IGF2BP3, MYC, SNAIL |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation; inhibits migration; suppresses metastasis; suppresses tumor growth |
| Molecular mechanism: |
acts as a protein decoy/sponge for IGF2BP3, reducing IGF2BP3-mediated stabilization of MYC mRNA and inhibiting MYC and SNAIL expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); metastasis (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Northern Blot; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Clinical Sample Validation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Western Blot; RNA-seq; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
plasma circ-TNPO3 could serve as a potential diagnostic biomarker; circ-TNPO3 expression correlated with differentiation of GC; no correlation with overall survival |
| Description: |
circ-TNPO3 is down-regulated in gastric cancer tissues and plasma and acts as a tumor suppressor by inhibiting proliferation and migration/metastasis. Mechanistically, it binds IGF2BP3 as a protein decoy, weakening IGF2BP3-mediated stabilization of MYC mRNA and reducing MYC and downstream SNAIL expression. Plasma circ-TNPO3 shows potential diagnostic value, but it is not associated with overall survival in this study. |
| Confidence score: |
0.8944 |