| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
participates in intercellular communication (release and uptake between cancer and non-cancer lung cells) |
| Molecular mechanism: |
exported as extracellular RNA; uptake via conditioned media or purified EVs; protected by EV membranes in PC9 |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; FISH / smFISH; RNase R Treatment; Clinical Sample Validation |
| Clinical significance: |
circ 3_2 LSD1-RNAs were significantly fewer in LUAD tissues compared to matching non-tumor areas |
| Description: |
circ 3_2 (a KDM1A-derived circLSD1 RNA) is down-regulated in LUAD tumor tissues versus matched non-tumor tissues. It is also detectable as extracellular RNA and can be transferred between lung cancer and non-cancer epithelial cells, consistent with a role in EV/RNP-mediated intercellular communication. |
| Confidence score: |
0.5909 |