| Expression pattern: |
UP |
| Associated gene: |
ZFP36L2, Ki67, PCNA, Bax, Bcl-2 |
| Associated microRNA: |
miR-429 |
| Biological function: |
Promotes gastric cancer cell growth, proliferation, colony formation, invasion and xenograft tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0003789 functions as a ceRNA/miRNA sponge for miR-429, thereby upregulating ZFP36L2 expression and promoting gastric cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; EdU Staining; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0003789 upregulation is positively associated with poor tumor differentiation, clinical advanced stage, and distal metastasis; it may be a therapeutic target for gastric cancer. |
| Description: |
circ_0003789 is up-regulated in gastric cancer tissues and cells. It promotes gastric cancer progression by sponging miR-429 and increasing ZFP36L2 expression, thereby enhancing proliferation, colony formation, invasion and xenograft tumor growth while suppressing apoptosis. The study suggests circ_0003789 may be a therapeutic target for gastric cancer. |
| Confidence score: |
0.7597 |