circRNA basic information
circBase ID: hsa_circ_0006220
Name: hsa_circ_TADA2A
Synonym: -
Host Gene: TADA2A
Genomic location(hg19): chr17:35800605-35800763:+
Genomic location(hg38): chr17:37440504-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ESR1, KDR
Associated microRNA: miR-221-3p, miR-222-3p
Biological function: Associated with sorafenib resistance of HCC (bioinformatically inferred).
Molecular mechanism: Putative circRNA-miRNA-mRNA regulatory axis (ceRNA-like) involving miR-221/222-3p and ESR1/KDR in sorafenib resistance of HCC.
Biological pathway or process:

ceRNA regulation (other); drug resistance (promotes)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; Survival Analysis; ROC Analysis
Clinical significance:

-
Description:

Using circRNA microarray data (GSE101850) and downstream database analyses, hsa_circ_0006220 was identified as down-regulated in sorafenib-resistant vs sorafenib-sensitive HCC samples. The study proposes a putative regulatory axis in which hsa_circ_0006220 interacts with miR-221-3p/miR-222-3p and relates to ESR1 and KDR in sorafenib resistance, without experimental functional validation.
Confidence score:

0.459
Other information
Title:

Bioinformatic analysis shows the correlation of hsa_circ_0006220-miR-221/222-3p-ESR1/KDR axis with sorafenib resistance of hepatocellular carcinoma.

Journal: Non-coding RNA research
Published: 2024
PubMed ID: 38075197
Study type:

bioinformatics study
Data availability: GSE101850; https://doi.org/10.1016/j.ncrna.2023.11.001
Code availability: -