| Expression pattern: |
UP |
| Associated gene: |
VCAN |
| Associated microRNA: |
miR-587 |
| Biological function: |
promotes proliferation, migration, and invasion; suppresses apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circ-0002570 acts as a miRNA sponge for miR-587, relieving miR-587-mediated repression of VCAN |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); EMT (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; ISH (In Situ Hybridization); FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; TUNEL; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ-0002570 expression is frequent in GC patients and is associated with shorter overall survival / poor prognosis. |
| Description: |
Circ-0002570 (hsa_circ_0002570), derived from FAM73A, is up-regulated in gastric cancer tissues and cell lines and predicts poor survival. It promotes proliferation, migration, invasion, and tumor growth by sponging miR-587 to de-repress VCAN, forming a circ-0002570/miR-587/VCAN ceRNA axis. |
| Confidence score: |
0.8847 |