| Expression pattern: |
UP |
| Associated gene: |
RBPJ |
| Associated microRNA: |
miR-433-3p |
| Biological function: |
circ_0001535 functions as an oncogenic circRNA in CRC, promoting cell proliferation, migration, invasion, angiogenesis and in vivo tumor growth while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0001535 acts as a ceRNA sponge for miR-433-3p, relieving miR-433-3p-mediated repression of RBPJ and thereby increasing RBPJ expression in CRC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0001535 may be a potential therapeutic target for CRC. |
| Description: |
Hsa_circ_0001535/circ_0001535 is up-regulated in CRC tissues and cell lines. It promotes CRC progression by enhancing proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. Mechanistically, circ_0001535 acts as a ceRNA for miR-433-3p to up-regulate RBPJ, suggesting that targeting the circ_0001535/miR-433-3p/RBPJ axis may have therapeutic value in CRC. |
| Confidence score: |
0.8006 |