circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NPC tissues; normal paracancerous tissues
Cell lines:

C666-1; 5-8F; NP69
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ELF2
Associated microRNA: miR-188
Biological function: promotes cell proliferation and cell cycle transition; inhibits apoptosis
Molecular mechanism: circ-ZNF609 acts as a sponge for miR-188 to regulate ELF2 expression
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot
Clinical significance:

-
Description:

circ-ZNF609 is up-regulated in nasopharyngeal carcinoma tissues/cells and promotes NPC cell growth. Mechanistically, circ-ZNF609 sponges miR-188, thereby relieving miR-188-mediated repression of ELF2, which enhances proliferation/cell-cycle progression and reduces apoptosis.
Confidence score:

0.6811
Other information
Title:

CircRNA ZNF609 Knockdown Suppresses Cell Growth via Modulating miR-188/ELF2 Axis in Nasopharyngeal Carcinoma.

Journal: OncoTargets and therapy
Published: 2020
PubMed ID: 32273713
Study type:

combined biological and clinical study
Data availability: -
Code availability: -