| Expression pattern: |
UP |
| Associated gene: |
P38 MAPK, JAK/STAT, p-p38, p-JAK2, p-STAT1 |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
Promotes proliferation and invasion and tumor growth; inhibits apoptosis in PTC. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-195-5p and modulates P38 MAPK and JAK/STAT signaling (p38/JAK2/STAT1 phosphorylation). |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); MAPK (promotes); JAK/STAT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
High CircRNA NRIP1 levels were correlated with advanced PTC stage. |
| Description: |
CircRNA NRIP1 is up-regulated in papillary thyroid carcinoma tissues and cell lines and is associated with advanced stage. It promotes PTC cell proliferation and invasion and inhibits apoptosis by sponging miR-195-5p, thereby activating P38 MAPK and JAK/STAT signaling (increased p-p38, p-JAK2, p-STAT1) and enhancing xenograft tumor growth. |
| Confidence score: |
0.8001 |