circRNA basic information
circBase ID: -
Name: hsa_circ_KCNN2
Synonym: circ 418-KCNN2
Host Gene: KCNN2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004981
MONDO name: atrial fibrillation
Disease details: atrial fibrillation
Disease DO ID:
 0060224
Disease MeSH ID:
 D001281
Disease NCIt ID:
 C50466
Disease ICD11 ID:
 171698302
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

left atrial appendage / LAA
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: RELA
Associated microRNA: hsa-miR-302a-3p, hsa-miR-302b-3p, hsa-miR-302c-3p, hsa-miR-302d-3p
Biological function: may regulate RELA (p65) via a miRNA cluster
Molecular mechanism: circRNA-miRNA-mRNA regulatory network (predicted miRNA sponge effect)
Biological pathway or process:

ceRNA regulation (other); NF-kappaB (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circ 418-KCNN2 is down-regulated in valvular persistent AF LAA tissue. Network analysis suggests it may act via a ceRNA-like mechanism affecting the miR-302a/b/c/d-3p cluster to regulate RELA (p65), implicating inflammatory/NF-kappaB-related signaling in AF.
Confidence score:

0.585
Other information
Title:

Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.

Journal: Frontiers in cardiovascular medicine
Published: 2020
PubMed ID: 33330659
Study type:

combined biological and clinical study
Data availability: PRJNA667522
Code availability: -