circRNA basic information
circBase ID: hsa_circ_0003998
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr20:47570092-47580435:+
Genomic location(hg38): chr20:48953555-48963898:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LAD tissues; adjacent normal tissues
Cell lines:

A549; H1299; A549/DTX; H1299/DTX
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SP1
Associated microRNA: miR-326
Biological function: Promotes docetaxel chemoresistance; promotes proliferation and inhibits apoptosis in docetaxel-resistant LAD cells (knockdown decreases chemoresistance, inhibits proliferation, and enhances apoptosis).
Molecular mechanism: Acts as a miRNA sponge by directly binding miR-326; miR-326 mediates the effect of hsa_circ_0003998 on chemosensitivity, suggesting a hsa_circ_0003998/miR-326/SP1 pathway.
Biological pathway or process:

chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry
Clinical significance:

Inactivation of hsa_circ_0003998 could be a novel approach for the treatment of LAD chemoresistance.
Description:

hsa_circ_0003998 is up-regulated in LAD tissues and docetaxel-resistant LAD cell lines and promotes docetaxel chemoresistance. It directly binds (sponges) miR-326, and miR-326 mediates the effect of hsa_circ_0003998 on chemosensitivity, implicating a hsa_circ_0003998/miR-326/SP1 axis.
Confidence score:

0.6479
Other information
Title:

Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326 in Lung Adenocarcinoma Cells.

Journal: Oncology research
Published: 2019
PubMed ID: 30764896
Study type:

combined biological and clinical study
Data availability: -
Code availability: -