| Expression pattern: |
DN |
| Associated gene: |
MTDH |
| Associated microRNA: |
miR-1471 |
| Biological function: |
Suppresses gastric cancer cell proliferation, invasion, and migration (tumor suppressor effect). |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-1471 to regulate MTDH expression, forming the circITGA7/miR-1471/MTDH axis. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; CCK8; Transwell Assay |
| Clinical significance: |
- |
| Description: |
circITGA7 is downregulated in gastric cancer tissues/cell lines and functions as a tumor suppressor by inhibiting proliferation and metastatic behaviors. Mechanistically, it sponges miR-1471 to regulate the downstream target MTDH, forming a circITGA7/miR-1471/MTDH axis that modulates GC progression. |
| Confidence score: |
0.6676 |