| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes cell cycle progression; inhibits apoptosis |
| Molecular mechanism: |
Predicted ceRNA network (circNFIA-mediated) based on circBank and miRDB; pathway enrichment suggests involvement of PI3K-Akt and MAPK signaling. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); PI3K/AKT (other); MAPK (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis; Microarray |
| Clinical significance: |
circNFIA is overexpressed in prostate cancer tissues and plasma samples and is suggested as a potential diagnostic biomarker. |
| Description: |
circNFIA is up-regulated in prostate cancer tissues, cell lines, and patient plasma. Functional knockdown suggests it promotes proliferation and cell-cycle progression while suppressing apoptosis. A bioinformatically predicted ceRNA network indicates potential involvement of PI3K-Akt and MAPK signaling via circRNA-miRNA-mRNA regulation. |
| Confidence score: |
0.6046 |