circRNA basic information
circBase ID: hsa_circ_0001181
Name: hsa_circ_BACH1
Synonym: -
Host Gene: BACH1
Genomic location(hg19): chr21:30693541-30702014:+
Genomic location(hg38): chr21:29321220-29329693:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007959
MONDO name: medulloblastoma
Disease details: medulloblastoma
Disease DO ID:
 0050902, 0060104
Disease MeSH ID:
 D008527
Disease NCIt ID:
 C3222
Disease ICD11 ID:
 290815825
Disease OMIM ID:
 155255
Species: Human
Species details: Homo sapiens
Tissue specimen:

medulloblastoma tumor tissue; cerebellum
Cell lines:

Daoy; UW-228
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Minimal impact on medulloblastoma cell proliferation upon depletion or overexpression.
Molecular mechanism: Not specified; differential splicing/back-splicing regulation independent of corresponding linear mRNAs.
Biological pathway or process:

proliferation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; MTT
Clinical significance:

-
Description:

hsa_circ_0001181 (BACH1 circRNA) is down-regulated in SHH-subtype medulloblastoma versus cerebellum while the linear BACH1 mRNA is unchanged. Knockdown or overexpression does not significantly alter proliferation in Daoy and UW-228 cells.
Confidence score:

0.7059
Other information
Title:

Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.

Journal: Cancers
Published: 2021
PubMed ID: 34680287
Study type:

combined biological and clinical study
Data availability: GSE183194
Code availability: -