| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Minimal impact on medulloblastoma cell proliferation upon depletion or overexpression. |
| Molecular mechanism: |
Not specified; differential splicing/back-splicing regulation independent of corresponding linear mRNAs. |
| Biological pathway or process: |
proliferation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; MTT |
| Clinical significance: |
- |
| Description: |
hsa_circ_0000915 (FKBP8 circRNA) is down-regulated in SHH-subtype medulloblastoma compared with normal cerebellum while its corresponding linear mRNA is unchanged. Functional perturbation (siRNA knockdown or overexpression) shows minimal effects on proliferation in medulloblastoma cell lines. |
| Confidence score: |
0.7059 |