| Expression pattern: |
UP |
| Associated gene: |
PD-L1, NF-kappaB p65, c-Myc, COX-2 |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration, invasion/metastasis and tumorigenesis of HCC. |
| Molecular mechanism: |
Activates NF-kappaB signaling (increases p65 phosphorylation), upregulates c-Myc and COX-2, leading to increased PD-L1 expression. |
| Biological pathway or process: |
NF-kappaB (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Sanger Sequencing; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; RNA-seq; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circCORO1C is a promising biomarker and therapeutic target for HCC. |
| Description: |
circCORO1C is up-regulated in HCC tissues and promotes HCC cell proliferation, migration/invasion and xenograft tumor growth. It enhances PD-L1 expression by activating NF-kappaB signaling, increasing p65 phosphorylation and upregulating c-Myc and COX-2. |
| Confidence score: |
0.6502 |