| Expression pattern: |
UP |
| Associated gene: |
AIFM2, Ago2 |
| Associated microRNA: |
miR‐1228 |
| Biological function: |
Promotes proliferation, invasion/infiltration and metastasis of HER-2-positive breast cancer cells; inhibits ferroptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1228 to relieve repression of AIFM2, increasing AIFM2 expression and affecting ferroptosis-related pathways. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (promotes); ferroptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; H&E Staining; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Clinical Sample Validation |
| Clinical significance: |
circGFRA1 is upregulated in HER-2-positive breast cancer tissues and suggested to have prognostic and therapeutic value; proposed as a promising treatment option. |
| Description: |
circGFRA1 (hsa_circ_005239), derived from the GFRA1 gene, is up-regulated in HER-2-positive breast cancer cells and tissues. It promotes malignant behaviors (proliferation, invasion and metastasis) and inhibits ferroptosis by sponging miR-1228 to enhance AIFM2 expression (circGFRA1/miR-1228/AIFM2 ceRNA axis). |
| Confidence score: |
0.8069 |