| Expression pattern: |
UP |
| Associated gene: |
hexokinase II (HK2) |
| Associated microRNA: |
miR-125b |
| Biological function: |
Promotes HCC cell proliferation, migration and glycolysis; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-125b to up-regulate HK2. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0001806 expression was associated with advanced TNM stage, metastasis and lower survival rate in HCC patients. |
| Description: |
hsa_circ_0001806 is up-regulated in HCC and associated with advanced disease and poor overall survival. Functionally it promotes proliferation, migration and glycolysis and inhibits apoptosis. Mechanistically it sponges miR-125b to increase HK2 expression, forming a miR-125b/HK2 axis that mediates these malignant phenotypes. |
| Confidence score: |
0.7646 |