| Expression pattern: |
UP |
| Associated gene: |
BCAS2, AGO2 |
| Associated microRNA: |
miR-382-5p |
| Biological function: |
promotes NSCLC cell proliferation, migration and invasion; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ_NEK6 sponges miR-382-5p to increase BCAS2 expression via RISCs |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_NEK6 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, migration and invasion while inhibiting apoptosis by sponging miR-382-5p to de-repress BCAS2 (circ_NEK6/miR-382-5p/BCAS2 axis). |
| Confidence score: |
0.8487 |